OICR-9429

Catalog No.S7833

OICR-9429 Chemical Structure

Molecular Weight(MW): 555.59

OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro.

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Biological Activity

Description OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro.
Targets
Wdr5-MLL interaction [1] WDR5 [1]
93 nM(Kd)
In vitro

OICR-9429 binds WDR5 with high affinity (Kd=93±28 nM) and competitively disrupts its interaction with a high-affinity Wdr5-interacting (WIN) peptide of MLL (Kdisp=64±4 nM)[1].

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: Primary human AML cells
  • Concentrations: 5 μM
  • Incubation Time: 72 h
  • Method: 20,000 viable, actively proliferating primary human AML cells per well were seeded in 96-well plates in triplicates and treated with 0.05% DMSO or OICR-9429. Cell viability was measured using the Cell Titer-Glo luminescent cell viability assay on a VICTOR X4 luminometer after 72 h.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 38 mg/mL (68.39 mM)
Ethanol 14 mg/mL (25.19 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 555.59
Formula

C29H32F3N5O3

CAS No. 1801787-56-3
Storage powder
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Related Antibodies

Histone Methyltransferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID