mGluR5 Selective Agonists | Antagonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2861 CTEP (RO4956371)

CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors.

Selective mGlu5, IC50: 2.2 nM
S2795 VU 0357121

VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes.

Selective mGluR5, EC50: 30 nM
S2809 MPEP

MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.

Selective mGluR5, IC50: 36 nM
S2690 ADX-47273

ADX47273 is a potent and specific mGlu5 positive allosteric modulator(PAM) with EC50 of 0.17 μM, showing no activity at other mGlu subtypes.

Selective mGlu5, EC50: 0.17 μM