Home GPCR & G Protein -Immunology & Inflammation CCR CCR5 Selective Inhibitors | Antagonists

CCR5 Selective Inhibitors | Antagonists

Catalog No.	Product Name	Information	Selective / Pan	IC50 / Ki
S8501	Adaptavir (DAPTA)	Adaptavir (DAPTA, D-Ala-peptide T-amide, peptide T) is a water soluble potent, selective CCR5 antagonist which potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5.	Selective	gp120 Bal-CCR5, IC50: 0.06 nM; CM235-CCR5, IC50: 0.32 nM
S3494	Vicriviroc maleate	Vicriviroc maleate(SCH-417690 maleate,SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells.	Selective	CCR5, Ki: 2.5 nM
S2003	Maraviroc	Maraviroc is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively. Maraviroc is used in the treatment of HIV infection.	Selective
S8512	Cenicriviroc	Cenicriviroc is a potent, orally active dual inhibitor of CC chemokine receptor 2 (CCR2) and CCR5. Cenicriviroc also inhibits HIV-1 and HIV-2 with potent anti-inflammatory and antiinfective activity.	Pan
S0085	BMS-813160	BMS-813160 is a potent, well-absorbed dual CCR2 and CCR5 chemokine antagonist. BMS-813160 inhibits inflammatory processes, angiogenesis, tumor cell migration, tumor cell proliferation and invasion.	Pan