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TRULI (Lats-IN-1) LATS inhibitor

Name: TRULI (Lats-IN-1)
Brand: Selleck Chemicals
SKU: E1061
Availability: InStock
Rating: 5 (7 reviews)

Cat.No.E1061

TRULI inhibits both Lats1 and Lats2 with a IC50 of 0.2 nM, suppresses Yap phosphorylation, induces cell proliferation in several cell lines and tissues, and promotes the initial stages of proliferative regeneration of the sensory receptors in the inner ear.

Chemical Structure

Molecular Weight: 334.40

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Quality Control

Batch: E106101 DMSO]67 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.98%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS/MSDS
Datasheet

99.98

Related Targets	YAP TEAD MAP4K MST
Other LATS Inhibitors	TDI-011536 GA-017 NIBR-LTSi

Solubility in DMSO or Water

In vitro
Batch:

DMSO : 67 mg/mL (200.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

The solubility data above are all experimental results (not literature values).

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.350mg/ml (10.02mM)	Taking the 1 mL working solution as an example, add 50 μL of 67 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Search directly for a cell line, or select a cell line to find matched working concentrations

Mechanism of Action

Information	TRULI (Lats-IN-1) is a pharmacological LATS inhibitor. It affects LATS signaling by inhibiting LATS activity, effectively promoting spheroid formation, colony formation, and proliferation in primary cervical loop progenitor and differentiated ameloblast cells.
Primary Applications and Mechanism of Action

Chemical Information, Storage & Stability

Molecular Weight	334.40	Formula	C₁₈H₁₄N₄OS	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	1424635-83-5	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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