Home Hippo LATS inhibitor GA-017 For research use only.

GA-017

GA-017 inhibits the serine/threonine protein kinases large tumor suppressor kinase 1/2 (LATS1/2), which exerts inhibitory with IC50s against LATS1 and 2 of 4.10±0.79 and 3.92±0.42 nM, respectively, and competitively inhibits LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58±0.11 and 0.25±0.03 nM, respectively.

GA-017 Chemical Structure

GA-017 Chemical Structure

CAS: 2351906-74-4

Purity & Quality Control

Batch: E114501 DMSO] 69 mg/mL] false] Ethanol] 35 mg/mL] false] Water] Insoluble] false Purity: 99.23%
99.23

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Biological Activity

Description GA-017 inhibits the serine/threonine protein kinases large tumor suppressor kinase 1/2 (LATS1/2), which exerts inhibitory with IC50s against LATS1 and 2 of 4.10±0.79 and 3.92±0.42 nM, respectively, and competitively inhibits LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58±0.11 and 0.25±0.03 nM, respectively.
Targets
LATS2 [1]
(in a double-reciprocal lineweaver-burk plot)		 LATS1 [1]
(in a double-reciprocal lineweaver-burk plot)		 LATS2 [1]
(in the kinase assay)		 LATS1 [1]
(in the kinase assay)
0.25 nM(Ki) 0.58 nM(Ki) 3.92 nM 4.10 nM

Chemical Information & Solubility

Molecular Weight 343.38 Formula

C18H21N3O4
CAS No. 2351906-74-4 SDF --
Smiles CC\C(=N\NC(=O)NCC1=CC(=CC=C1)O)C2=C(O)C(=C(O)C=C2)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 69 mg/mL ( (200.94 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 35 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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