Suzetrigine (VX-548): Selectivity & Specificity
Suzetrigine (VX-548) is a potent inhibitor of NaV1.8 (0.27 nM), NaV1.1 (>30000 nM), NaV1.2 (>30000 nM), NaV1.3 (>30000 nM), NaV1.4 (>30000 nM), NaV1.5 (>30000 nM), NaV1.6 (>30000 nM), NaV1.7 (>30000 nM), NaV1.9 (>30000 nM), sodium channels (200 nM). Suzetrigine (VX-548) exhibits the greatest inhibitory potency toward NaV1.8 (IC50 = 0.27 nM).