2D Structure
loading...
2D chemical structural formula diagram.
3D Structure
loading...
This 3D model represents a theoretically simulated conformation and is for reference only.
Check the
Suzetrigine (VX-548)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carbonyl]amino]pyridine-2-carboxamide | |
|---|---|---|
| CAS Number | 2649467-58-1 | |
| Molecular Formula |
C21H20F5N3O4 |
|
| Molecular Weight (MW) | 473.39 | |
| InChIKey | XSQUJFKRXZMOKA-PAFIKIDNSA-N |
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(200.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 23 mg/mL |
| Water | Insoluble |
| DMSO |
95 mg/mL
(200.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
| DMSO |
95 mg/mL
(200.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 11 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Suzetrigine (VX-548) Mechanism of Action: NaV1.8 Inhibition in Nociceptive Sensory Neuron Research
- Suzetrigine (VX-548) Clinical Trials
- Suzetrigine (VX-548): Selectivity & Specificity
- Suzetrigine (VX-548) Working Concentration | Cell Culture | Treatment
- Suzetrigine (VX-548) Solubility in DMSO
- Suzetrigine (VX-548) Stock Solution
- Suzetrigine (VX-548) Storage
- Suzetrigine (VX-548) Stability
- Suzetrigine (VX-548) Combination Database
- Suzetrigine (VX-548) Molecular Weight
- Suzetrigine (VX-548) CAS Number
- Suzetrigine (VX-548) IC50 for Cell-based and Cell-free Assays
- Suzetrigine (VX-548) Sigma (AMBH9A2606B7)? Try a better option.
- Suzetrigine (VX-548) MedChemExpress (HY-148800)? Try a better option.
- Suzetrigine (VX-548) Cayman (40799)? Try a better option.
- Suzetrigine (VX-548) APExBIO (BA6958)? Try a better option.
- Suzetrigine (VX-548) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.