CAS No. 2649467-58-1

Batch: Purity:97.98
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Suzetrigine (VX-548) Chemical Structure
Chemical Structure
Check the Suzetrigine (VX-548) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carbonyl]amino]pyridine-2-carboxamide
CAS Number 2649467-58-1
Molecular Formula

C21H20F5N3O4
Molecular Weight (MW) 473.39
InChIKey XSQUJFKRXZMOKA-PAFIKIDNSA-N

Ordering Information

Biological Activity

Suzetrigine (VX-548) is an orally active, potent, and selective inhibitor of voltage-gated sodium channel 1.8 (NaV1.8). It exhibits state-dependent channel blockade in primary pain-sensing neurons. Selective inhibition of NaV1.8 channels suppresses action potential firing in primary afferent nociceptors and dampens downstream nociceptive signal transmission pathways without affecting central nervous system function. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 95 mg/mL (200.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 23 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.