Suzetrigine (VX-548) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

Product Name: Suzetrigine (VX-548)
Catalog Number: E1612
CAS Number: 2649467-58-1
IUPAC Name: 4-[[[(2R ,3S ,4S ,5R )-3-(3,4-Difluoro-2-methoxy phenyl)tetrahydro-4,5-dimethyl-5-(trifluor omethyl)-2-furanyl]carbonyl]amino]-2- pyridinecarboxamide

Relevant identified uses and uses advised against

Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

Company : Selleck Chemicals
TollFree : +1 877 796-6397
Tel : +1 832 582-8158
Fax : +1 832 582-8590

Emergency telephone number

Emergency phone #: +1 832 582-8158

2. HAZARDS IDENTIFICATION

2.1 Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS):

Acute toxicity, oral (Category 4), H302
Skin corrosion/irritation (Category 2), H315
Serious eye damage/eye irritation (Category 2A), H319

2.2 GHS Label elements, including precautionary statements
Pictogram: GHS07
Signal word: Warning

Hazard statement(s):

H302: Harmful if swallowed
H315: Causes skin irritation
H319: Causes serious eye irritation

Precautionary statement(s):
Prevention:

P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.

Response:

P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P330: Rinse mouth.
P362+P364: Take off contaminated clothing and wash it before reuse.

Disposal:

P501: Dispose of contents/container in accordance with local regulation.

2.3 Other hazards
None.

3. COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substances

Synonyms: VX-548
Formula: 4-[[[(2R ,3S ,4S ,5R )-3-(3,4-Difluoro-2-methoxy phenyl)tetrahydro-4,5-dimethyl-5-(trifluor omethyl)-2-furanyl]carbonyl]amino]-2- pyridinecarboxamide
Molecular Weight: 473.39
CAS No.: 2649467-58-1

4. FIRST AID MEASURES

4.1 Description of first aid measures

Eye contact: Remove contact lenses if present. Immediately flush eyes with large amounts of water, separating eyelids with fingers to ensure thorough rinsing. Promptly contact a physician.
Skin contact: Thoroughly rinse skin with large amounts of water. Remove contaminated clothing and shoes. Contact a physician.
Inhalation: Move the individual to fresh air immediately. If breathing is difficult, administer cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.
Ingestion: Wash out mouth with water. Do NOT induce vomiting. Contact a physician.

4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the hazard labelling (see section 2.2).

4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically.

5. FIRE FIGHTING MEASURES

5.1 Extinguishing media
Use water spray, dry chemical, foam, or carbon dioxide fire extinguishers.

5.2 Special hazards arising from the substance or mixture
Irritant fumes may be emitted during combustion.

5.3 Advice for firefighters

Special protective equipment: Firefighters should use personal protective equipment.
Specific extinguishing methods: Use measures appropriate to local circumstances and the surrounding environment. Evacuate personnel to safe areas and remove undamaged containers if safe to do so.

6. ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions, protective equipment and emergency procedures
Use full personal protective equipment. Avoid breathing vapors, mist, dust, or gas. Ensure adequate ventilation and evacuate personnel to safe areas. Refer to protective measures in Section 8.

6.2 Environmental precautions
Prevent further leakage or spillage. Do not allow the product to enter drains or water courses.

6.3 Methods and materials for containment and cleaning up
Absorb solutions with finely-powdered liquid-binding material (such as diatomite or universal binders). Decontaminate surfaces and equipment by scrubbing with alcohol. Dispose of contaminated material according to Section 13.

6.4 Reference to other sections
For disposal instructions, see section 13.

7. HANDLING AND STORAGE

7.1 Precautions for safe handling
Avoid inhalation and contact with eyes and skin. Avoid the formation of dust and aerosols. Use only in areas equipped with appropriate exhaust ventilation.

7.2 Conditions for safe storage, including any incompatibilities
Keep containers tightly sealed in a cool, well-ventilated area. Store away from direct sunlight and sources of ignition.
Recommended storage temperature:

powder: -20°C for 3 years
In solvent: -80°C for 6 months; -20°C for 1 month
Shipping at room temperature is acceptable if for less than 2 weeks.

7.3 Specific end use(s)
N/A.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1 Control parameters
This product contains no substances with occupational exposure limit values.

8.2 Exposure controls

Engineering controls: Ensure adequate ventilation. Provide accessible safety showers and eye wash stations.
Personal protective equipment:
- Eye protection: Safety goggles with side-shields.
- Hand protection: Protective gloves.
- Skin and body protection: Impervious clothing.
- Respiratory protection: Suitable respirator.
Environmental exposure controls: Keep product away from drains, water courses, or soil. Clean spillages safely and promptly.

9. PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on basic physical and chemical properties

Appearance: powder
Odor: N/A
Odor threshold: N/A
pH: N/A
Melting/freezing point: N/A
Boiling point/range: N/A
Flash point: N/A
Evaporation rate: N/A
Flammability (solid, gas): N/A
Upper/lower flammability or explosive limits: N/A
Vapor pressure: N/A
Vapor density: N/A
Relative density: N/A
Water Solubility: N/A
Partition coefficient: N/A
Auto-ignition temperature: N/A
Decomposition temperature: N/A
Viscosity: N/A
Explosive properties: N/A
Oxidizing properties: N/A

9.2 Other safety information
N/A.

10. STABILITY AND REACTIVITY

10.1 Reactivity
N/A.

10.2 Chemical stability
Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions
N/A.

10.4 Conditions to avoid
N/A.

10.5 Incompatible materials
Strong acids/alkalis, strong oxidising/reducing agents.

10.6 Hazardous decomposition products
Under fire conditions, may decompose and emit toxic fumes. Other decomposition products: no data available.

11. TOXICOLOGICAL INFORMATION

11.1 Information on toxicological effects

Acute toxicity: Classified based on available data; see section 2.
Skin corrosion/irritation: Classified based on available data; see section 2.
Serious eye damage/irritation: Classified based on available data; see section 2.
Respiratory or skin sensitization: Classified based on available data; see section 2.
Germ cell mutagenicity: Classified based on available data; see section 2.
Carcinogenicity:
- IARC: No component present at 0.1% or greater is identified as a probable, possible or confirmed human carcinogen.
- ACGIH: No component present at 0.1% or greater is identified as a potential or confirmed carcinogen.
- NTP: No component present at 0.1% or greater is identified as an anticipated or confirmed carcinogen.
- OSHA: No component present at 0.1% or greater is identified as a potential or confirmed carcinogen.
Reproductive toxicity: Classified based on available data; see section 2.
Specific target organ toxicity - single exposure: Classified based on available data; see section 2.
Specific target organ toxicity - repeated exposure: Classified based on available data; see section 2.
Aspiration hazard: Classified based on available data; see section 2.
Additional information: Chemical, physical, and toxicological properties have not been completely investigated.

12. ECOLOGICAL INFORMATION

12.1 Toxicity
N/A.

12.2 Persistence and degradability
N/A.

12.3 Bioaccumulative potential
N/A.

12.4 Mobility in soil
N/A.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.

12.6 Other adverse effects
N/A.

13. DISPOSAL CONSIDERATIONS

13.1 Waste treatment methods

Product: Dispose of the substance in accordance with prevailing country, federal, state, and local regulations.
Contaminated packaging: Conduct recycling or disposal in accordance with prevailing country, federal, state, and local regulations.

14. TRANSPORT INFORMATION

DOT (US)
Proper shipping name: Not dangerous goods
UN number: -
Class: -
Packing group: -

IMDG
Proper shipping name: Not dangerous goods
UN number: -
Class: -
Packing group: -

IATA
Proper shipping name: Not dangerous goods
UN number: -
Class: -
Packing group: -

15. REGULATORY INFORMATION

SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis)
reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
No SARA Hazards.
Massachusetts Right To Know Components:
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know Components:
No components are subject to the Pennsylvania Right to Know Act.
New Jersey Right To Know Components:
No components are subject to the New Jersey Right to Know Act.
California Prop. 65 Components:
This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive
harm.

16. OTHER INFORMATION

Revision Date: 2026/07/21
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.