Suzetrigine (VX-548) is a potent, highly selective NaV1.8 inhibitor. It affects peripheral nociceptive signaling by blocking sodium ion influx through NaV1.8 channels in sensory neurons, inhibiting action potential propagation to effectively alleviate acute and chronic pain.
Suzetrigine (VX-548) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Suzetrigine (VX-548) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.