BIBF 1120 (Nintedanib) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

Product Name: BIBF 1120 (Nintedanib)
Catalog Number: S1010
CAS Number: 656247-17-5
IUPAC Name: (Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

Relevant identified uses and uses advised against

Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

Company : Selleck Chemicals
TollFree : +1 877 796-6397
Tel : +1 832 582-8158
Fax : +1 832 582-8590

Emergency telephone number

Emergency phone #: +1 832 582-8158

2. HAZARDS IDENTIFICATION

GHS classification in accordance with the OSHA Hazard Communication Standard (29 CFR 1910.1200)

Acute toxicity (Oral): Category 3
Skin irritation: Category 2
Serious eye damage: Category 1
Reproductive toxicity: Category 2
Specific target organ toxicity - repeated exposure: Category 1

GHS label elements
Pictogram: GHS06 , GHS05 , GHS08

Signal word: Danger
Hazard statements:
- H301: Toxic if swallowed.
- H315: Causes skin irritation.
- H318: Causes serious eye damage.
- H361: Suspected of damaging fertility or the unborn child.
- H372: Causes damage to organs through prolonged or repeated exposure.
Precautionary statements:
- Prevention:
  - P201: Obtain special instructions before use.
  - P202: Do not handle until all safety precautions have been read and understood.
  - P260: Do not breathe powder.
  - P264: Wash skin thoroughly after handling.
  - P270: Do not eat, drink or smoke when using this product.
  - P280: Wear protective gloves/ protective clothing/ eye protection/ face protection.
- Response:
  - P301 + P310 + P330: IF SWALLOWED: Immediately call a POISON CENTER/ doctor. Rinse mouth.
  - P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
  - P305 + P351 + P338 + P310: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/ doctor.
  - P308 + P313: IF exposed or concerned: Get medical advice/ attention.
  - P332 + P313: If skin irritation occurs: Get medical advice/ attention.
  - P362: Take off contaminated clothing and wash before reuse.
- Storage:
  - P405: Store locked up.
- Disposal:
  - P501: Dispose of contents/ container to an approved waste disposal plant.

Other hazards
None known.

3. COMPOSITION/INFORMATION ON INGREDIENTS

Substance / Mixture: Substance
Chemical Name: (Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
CAS-No.: 656247-17-5
Concentration (% w/w): >= 90 - <= 100%

4. FIRST AID MEASURES

General advice: Show this safety data sheet to the doctor in attendance.
If inhaled: After inhalation: fresh air. Call in physician.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
In case of eye contact: After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.
If swallowed: Give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible.
Most important symptoms and effects, both acute and delayed: The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11.
Protection of first-aiders: For personal protection see section 8.
Notes to physician: N/A.

5. FIREFIGHTING MEASURES

Suitable extinguishing media: Water, Foam, Carbon dioxide (CO2), Dry powder.
Unsuitable extinguishing media: For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during fire fighting: Combustible. Development of hazardous combustion gases or vapours possible in the event of fire.
Hazardous combustion products: Carbon oxides, Nitrogen oxides (NOx).
Specific extinguishing methods: N/A.
Further information: Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters: Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures: Advice for non-emergency personnel: Avoid generation and inhalation of powder in all circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.
Environmental precautions: Do not let product enter drains.
Methods and materials for containment and cleaning up: Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of powder.

7. HANDLING AND STORAGE

Advice on safe handling: Work under hood. Do not inhale substance/mixture. For precautions see section 2.
Further information on storage conditions: Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorised persons.
Storage class: 6.1C, Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects.
Recommended storage temperature: 36 - 46 °F / 2 - 8 °C.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Ingredients with workplace control parameters: Contains no substances with occupational exposure limit values.
Engineering measures: N/A.
Personal protective equipment:
- Respiratory protection: Required when powder is generated. Recommended Filter type: Filter type P3. Maintenance, cleaning, and testing must be carried out according to producer instructions and properly documented.
- Hand protection: Handle with impervious gloves. Nitrile rubber gloves are recommended (0.11 mm thickness, 480 min breakthrough time) for both full and splash contact.
- Eye protection: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166 (EU). Tightly fitting safety goggles.
- Skin and body protection: Protective clothing.
- Hygiene measures: Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance: powder
Color: light yellow
Odor: N/A
Odor Threshold: N/A
pH: N/A
Melting point: N/A
Boiling point/boiling range: N/A
Flash point: Not applicable
Evaporation rate: N/A
Flammability (solid, gas): N/A
Flammability (liquids): N/A
Burning rate: N/A
Upper/Lower explosion limit: N/A
Vapor pressure: N/A
Relative vapour density: N/A
Relative density: N/A
Density: N/A
Water solubility: N/A
Partition coefficient: n-octanol/water: N/A
Autoignition temperature: N/A
Decomposition temperature: N/A
Viscosity (dynamic/kinematic): N/A
Flow time: N/A
Explosive properties: N/A
Oxidizing properties: None
Molecular weight: 539.62 g/mol
Particle size: N/A

10. STABILITY AND REACTIVITY

Reactivity: Flammable organic substances in fine distribution may generally assume a powder explosion potential when whirled up.
Chemical stability: The product is chemically stable under standard ambient conditions (room temperature).
Possibility of hazardous reactions: N/A.
Conditions to avoid: No information available.
Incompatible materials: N/A.
Hazardous decomposition products: In the event of fire: see section 5.

11. TOXICOLOGICAL INFORMATION

Acute toxicity: Acute toxicity estimate Oral - 100.1 mg/kg (Expert judgement). Remarks: Toxic by ingestion. Inhalation and Dermal data are not available.
Skin corrosion/irritation: Causes skin irritation.
Serious eye damage/eye irritation: Causes serious eye damage.
Respiratory or skin sensitization: N/A.
Germ cell mutagenicity: N/A.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as a probable, possible, or confirmed human carcinogen by IARC, NTP, or OSHA.
Reproductive toxicity: Suspected human reproductive toxicant. Suspected of damaging fertility or the unborn child.
Specific target organ toxicity - single exposure: N/A.
Specific target organ toxicity - repeated exposure: Causes damage to organs through prolonged or repeated exposure.
Aspiration hazard: N/A.
Additional Information: To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

12. ECOLOGICAL INFORMATION

Ecotoxicity: N/A.
Persistence and degradability: N/A.
Bioaccumulative potential: N/A.
Mobility in soil: N/A.
Other adverse effects: N/A.
Endocrine disrupting properties: N/A.

13. DISPOSAL CONSIDERATIONS

Disposal methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

14. TRANSPORT INFORMATION

International Regulations (IATA-DGR)

UN/ID No.: UN 2811
Proper shipping name: Toxic powder, organic, n.o.s. (Nintedanib)
Class: 6.1
Packing group: III
Labels: Division 6.1 - Toxic substances
Packing instruction (cargo/passenger aircraft): 677 / 670

International Regulations (IMDG-Code)

UN number: UN 2811
Proper shipping name: TOXIC POWDER, ORGANIC, N.O.S

16. OTHER INFORMATION

Revision Date: 2026/07/06
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.