CAS No. 656247-17-5
Batch:
Purity:99.82
Chemical Structure
Check the
BIBF 1120 (Nintedanib)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | methyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate | |
|---|---|---|
| CAS Number | 656247-17-5 | |
| Molecular Formula |
C31H33N5O4 |
|
| Molecular Weight (MW) | 539.62 | |
| SMILES | CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O | |
| InChIKey | CPMDPSXJELVGJG-UHFFFAOYSA-N |
BIBF 1120 (Nintedanib) is a triple angiokinase inhibitor targeting VEGFR1, VEGFR2, VEGFR3, FGFR1, FGFR2, FGFR3, PDGFRα, and PDGFRβ. It inhibits MAPK and AKT signaling pathways in endothelial cells, pericytes, and smooth muscle cells, resulting in suppressed proliferation and induced apoptosis. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(18.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
10 mg/mL
(18.53 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
17 mg/mL
(31.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
| DMSO |
18 mg/mL
(33.35 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
12 mg/mL
(22.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- BIBF 1120 (Nintedanib) Mechanism of Action: PDGFR Inhibition in Lung Fibroblast Research
- BIBF 1120 (Nintedanib) Clinical Trials
- BIBF 1120 (Nintedanib): Selectivity & Specificity
- BIBF 1120 (Nintedanib) Working Concentration | Cell Culture | Treatment
- BIBF 1120 (Nintedanib) Solubility in DMSO
- BIBF 1120 (Nintedanib) Stock Solution
- BIBF 1120 (Nintedanib) Storage
- BIBF 1120 (Nintedanib) Stability
- BIBF 1120 (Nintedanib) Combination Database
- BIBF 1120 (Nintedanib) Molecular Weight
- BIBF 1120 (Nintedanib) SMILES
- BIBF 1120 (Nintedanib) Chemical Structure (2D and 3D)
- BIBF 1120 (Nintedanib) IC50 for Cell-based and Cell-free Assays
- BIBF 1120 (Nintedanib) Sigma (SML2848)? Try a better option.
- BIBF 1120 (Nintedanib) MedChemExpress (HY-50904)? Try a better option.
- BIBF 1120 (Nintedanib) Cayman (11022)? Try a better option.
- BIBF 1120 (Nintedanib) APExBIO (A8252)? Try a better option.
- BIBF 1120 (Nintedanib) AbMole (M6197)? Try a better option.
- BIBF 1120 (Nintedanib) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.