2D Structure
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2D chemical structural formula diagram.
3D Structure
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This 3D model represents a theoretically simulated conformation and is for reference only.
Check the
BIBF 1120 (Nintedanib)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | methyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate | |
|---|---|---|
| CAS Number | 656247-17-5 | |
| Molecular Formula |
C31H33N5O4 |
|
| Molecular Weight (MW) | 539.62 | |
| SMILES | CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O | |
| InChIKey | CPMDPSXJELVGJG-UHFFFAOYSA-N |
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(18.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
10 mg/mL
(18.53 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
17 mg/mL
(31.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
| DMSO |
18 mg/mL
(33.35 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
12 mg/mL
(22.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- BIBF 1120 (Nintedanib) Mechanism of Action: PDGFR Inhibition in Lung Fibroblast Research
- BIBF 1120 (Nintedanib) Clinical Trials
- BIBF 1120 (Nintedanib): Selectivity & Specificity
- BIBF 1120 (Nintedanib) Working Concentration | Cell Culture | Treatment
- BIBF 1120 (Nintedanib) Solubility in DMSO
- BIBF 1120 (Nintedanib) Stock Solution
- BIBF 1120 (Nintedanib) Storage
- BIBF 1120 (Nintedanib) Stability
- BIBF 1120 (Nintedanib) Combination Database
- BIBF 1120 (Nintedanib) Molecular Weight
- BIBF 1120 (Nintedanib) SMILES
- BIBF 1120 (Nintedanib) CAS Number
- BIBF 1120 (Nintedanib) IC50 for Cell-based and Cell-free Assays
- BIBF 1120 (Nintedanib) Sigma (SML2848)? Try a better option.
- BIBF 1120 (Nintedanib) MedChemExpress (HY-50904)? Try a better option.
- BIBF 1120 (Nintedanib) Cayman (11022)? Try a better option.
- BIBF 1120 (Nintedanib) APExBIO (A8252)? Try a better option.
- BIBF 1120 (Nintedanib) AbMole (M6197)? Try a better option.
- BIBF 1120 (Nintedanib) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.