Lonafarnib (SCH66336) IC50 for Cell-based and Cell-free Assays

Cell-free Assays (IC₅₀/K_i) for Lonafarnib (SCH66336)

Key Target	IC₅₀ (Cell-free)	Description	Reference
No published data available.

Cell Type	IC₅₀ (Cell-based)	Description	Reference
Calu-3 cells (Wildtype SARS-CoV-2)	3.978 μM	Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) for extracellular viral RNA.	PMC9711904
Calu-3 cells (Delta SARS-CoV-2)	6.024 μM	Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) for extracellular viral RNA.	PMC9711904
HepNB2.7 cells	36 nM	In-cell ELISA (for HDAg quantification in primary and secondary infection), WST-1 assay (for cytotoxicity)	Download PDF
HEp-2 cells	0.04406 µM	RSV-P protein staining and flow cytometry	Download PDF
HEp-2 cells	0.01041 µM	RSV-P protein staining and flow cytometry	Download PDF
HEp-2 cells	0.1187 µM	RSV-P protein staining and flow cytometry	Download PDF
HEp-2 cells	0.06392 µM	RSV-P protein staining and flow cytometry	Download PDF
HEp-2 cells	0.02528 µM	RSV-P protein staining and flow cytometry	Download PDF
HEp-2 cells	0.08874 µM	RSV-P protein staining and flow cytometry	Download PDF

Check the Lonafarnib (SCH66336) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.