CAS No. 193275-84-2

Batch: Purity:99.48
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Lonafarnib (SCH66336) Chemical Structure
Chemical Structure
Check the Lonafarnib (SCH66336) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[2-[4-[(2R)-6,15-dibromo-13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl]piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxamide
CAS Number 193275-84-2
Molecular Formula

C27H31Br2ClN4O2
Molecular Weight (MW) 638.82
SMILES C1CN(CCC1CC(=O)N2CCC(CC2)C3C4=C(CCC5=C3N=CC(=C5)Br)C=C(C=C4Br)Cl)C(=O)N
InChIKey DHMTURDWPRKSOA-RUZDIDTESA-N

Ordering Information

Biological Activity

Lonafarnib (SCH66336) is an orally bioavailable farnesyltransferase inhibitor that potently inhibits human farnesyl protein transferase. By blocking farnesylation and Ras membrane association, Lonafarnib inhibits AKT signaling and suppresses downstream phosphorylation of glycogen synthase kinase-3. This inhibition leads to the suppression of cell proliferation and the induction of caspase-dependent apoptosis across multiple carcinoma cell lines. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 127 mg/mL (198.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 127 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.