CAS No. 356057-34-6

Batch: Purity:99.99
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Darapladib (SB-480848) Chemical Structure
Chemical Structure
Check the Darapladib (SB-480848) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[2-(diethylamino)ethyl]-2-[2-[(4-fluorophenyl)methylsulfanyl]-4-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-1-yl]-N-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]acetamide
CAS Number 356057-34-6
Molecular Formula

C36H38F4N4O2S
Molecular Weight (MW) 666.77
SMILES CCN(CC)CCN(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(F)(F)F)C(=O)CN3C4=C(CCC4)C(=O)N=C3SCC5=CC=C(C=C5)F
InChIKey WDPFJWLDPVQCAJ-UHFFFAOYSA-N

Biological Activity

Darapladib (SB-480848) is a potent, reversible inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) with an IC50 of. By inhibiting Lp-PLA2 activity, darapladib suppresses the hydrolysis of oxidized phospholipids, leading to decreased generation of lysophosphatidylcholine and oxidized free fatty acids. Consequently, this inhibition reduces vascular inflammation, attenuates necrotic core expansion, and inhibits the progression of advanced atherosclerotic lesions in preclinical models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (149.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Blackie JA, et al. Bioorg Med Chem Lett. 2003;13(6):1067-70.

[2] Wilensky RL, et al. Nat Med. 2008;14(10):1059-66.

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Note: Technical data last updated: Sep 1, 2026.