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CD2665 RAR/RXR antagonist

Name: CD2665
Brand: Selleck Chemicals
SKU: E6407
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E6407

CD2665 is an orally bioavailable selective antagonist of RAR-β and RAR-γ, exhibiting dissociation constants (Kd) of 306 nM for RAR-β and 110 nM for RAR-γ.

Chemical Structure

Molecular Weight: 486.60

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Quality Control

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Chemical Information, Storage & Stability

Molecular Weight	486.60	Formula	C31H34O5	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	170355-78-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

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In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

In vivo	CD2665 (0.6 mg/kg; Subcutaneous injection; daily, for 22 days) completely inhibits the overexpression of RARβ mRNA in the brain of alcohol treated mice. This compound is a selective retinoid antagonist and elicits the expected maturation delay and growth plate expansion.
References	[1] https://pubmed.ncbi.nlm.nih.gov/10651997/ [2] https://pubmed.ncbi.nlm.nih.gov/11696672/ [3] https://pubmed.ncbi.nlm.nih.gov/33724538/

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