Bardoxolone Methyl (RTA 402): Selectivity & Specificity

Bardoxolone Methyl (RTA 402) is a potent inhibitor of EGFRL858R/T790M (17.22 ± 5.26 nM), EGFRWT (175.70 ± 17.40 nM), NFE2L2, KEAP1, NFKB, IKBKB, STAT3, STAT5, AR, AR (splice variant AR-V7). Bardoxolone Methyl (RTA 402) exhibits the greatest inhibitory potency toward EGFRL858R/T790M (IC50 = 17.22 ± 5.26 nM).