CAS No. 218600-53-4

Batch: Purity:99.86
Check CoA
Bardoxolone Methyl (RTA 402) Chemical Structure
Chemical Structure
Check the Bardoxolone Methyl (RTA 402) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylate
CAS Number 218600-53-4
Molecular Formula

C32H43NO4
Molecular Weight (MW) 505.69
SMILES CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)OC)C
InChIKey WPTTVJLTNAWYAO-KPOXMGGZSA-N

Ordering Information

Biological Activity

Bardoxolone Methyl (RTA 402) is a synthetic oleanane triterpenoid that acts as an IκB kinase (IKK) inhibitor and Nrf2 activator. By inhibiting IKK and NF-κB signaling, it suppresses pro-inflammatory responses and promotes apoptosis in cancer cells. Concurrently, activation of the Nrf2 pathway enhances antioxidant gene expression, leading to cytoprotection and inhibition of ferroptosis. Through these dual pathways, Bardoxolone Methyl modulates cellular oxidative stress, survival, and autophagic responses. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 26 mg/mL (51.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Aliquotting Service

Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.

Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.

Jump to

Note: Technical data last updated: Sep 1, 2026.