Avapritinib (BLU-285): Selectivity & Specificity

Avapritinib (BLU-285) is a potent inhibitor of PDGFRA (14.49 nM), KIT D816V (0.27 nM), Kinase C-KIT (D816V) (2.81 ± 0.32 nM), KIT (0.27 nM). Avapritinib (BLU-285) exhibits the greatest inhibitory potency toward KIT D816V (IC50 = 0.27 nM).