2D Structure
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2D chemical structural formula diagram.
3D Structure
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This 3D model represents a theoretically simulated conformation and is for reference only.
Check the
Avapritinib (BLU-285)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine | |
|---|---|---|
| CAS Number | 1703793-34-3 | |
| Molecular Formula |
C26H27FN10 |
|
| Molecular Weight (MW) | 498.56 | |
| SMILES | CC(C1=CC=C(C=C1)F)(C2=CN=C(N=C2)N3CCN(CC3)C4=NC=NN5C4=CC(=C5)C6=CN(N=C6)C)N | |
| InChIKey | DWYRIWUZIJHQKQ-SANMLTNESA-N |
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(200.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1.5 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(200.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(200.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
66 mg/mL
(132.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(200.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Avapritinib (BLU-285) Mechanism of Action: KIT Inhibition in Mast Cell Research
- Avapritinib (BLU-285) Clinical Trials
- Avapritinib (BLU-285): Selectivity & Specificity
- Avapritinib (BLU-285) Working Concentration | Cell Culture | Treatment
- Avapritinib (BLU-285) Solubility in DMSO
- Avapritinib (BLU-285) Stock Solution
- Avapritinib (BLU-285) Storage
- Avapritinib (BLU-285) Stability
- Avapritinib (BLU-285) Combination Database
- Avapritinib (BLU-285) Molecular Weight
- Avapritinib (BLU-285) SMILES
- Avapritinib (BLU-285) CAS Number
- Avapritinib (BLU-285) IC50 for Cell-based and Cell-free Assays
- Avapritinib (BLU-285) Sigma (AMBH303C4C40)? Try a better option.
- Avapritinib (BLU-285) APExBIO (C8976)? Try a better option.
- Avapritinib (BLU-285) MedChemExpress (HY-101561)? Try a better option.
- Avapritinib (BLU-285) Cayman (22985)? Try a better option.
- Avapritinib (BLU-285) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.