Melanocortin Receptor

Inhibitory Selectivity

Melanocortin Receptor Products

Catalog No. Information Product Use Citations Product Validations
S0019

JNJ-10229570

JNJ-10229570 (UNII-N9IX402L35) is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R). JNJ-10229570 inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R with IC50 of 270 nM and 200 nM, respectively.
S0814New

THIQ

THIQ is a potent and selective agonist of melanocortin-4 receptor (MC4R) with IC50 of 1.2 nM and 0.6 nM for hMC4R and rMC4R, respectively.
E1002New

Setmelanotide (RM-493)

Setmelanotide (RM-493, BIM-22493, CAM 4072) is a cyclic peptide full agonist of melanocortin-4 receptor (MC4R) with an EC50 of 0.27 nM and a Ki of 2.1 nM.
Catalog No. Information Product Use Citations Product Validations
S0019

JNJ-10229570

JNJ-10229570 (UNII-N9IX402L35) is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R). JNJ-10229570 inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R with IC50 of 270 nM and 200 nM, respectively.
Catalog No. Information Product Use Citations Product Validations
S0814New

THIQ

THIQ is a potent and selective agonist of melanocortin-4 receptor (MC4R) with IC50 of 1.2 nM and 0.6 nM for hMC4R and rMC4R, respectively.
E1002New

Setmelanotide (RM-493)

Setmelanotide (RM-493, BIM-22493, CAM 4072) is a cyclic peptide full agonist of melanocortin-4 receptor (MC4R) with an EC50 of 0.27 nM and a Ki of 2.1 nM.