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IAP Antagonists

Cat.No. Product Name Information Product Use Citations Product Validations
S7015 Birinapant (TL32711) Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM in a cell-free assay, less potent to XIAP. This compound helps to induce apoptosis in latent HIV-1-infected cells. Phase 2.
Cell, 2025, S0092-8674(25)01233-4
Nat Commun, 2025, 16(1):7360
EMBO Mol Med, 2025, 10.1038/s44321-025-00201-x
Verified customer review of Birinapant (TL32711)
S7597 BV6 BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.
Nature, 2025, 647(8090):735-746
Nat Commun, 2025, 16(1):4919
EMBO J, 2025, 10.1038/s44318-025-00561-7
Verified customer review of BV6
S2754 Xevinapant (AT406) Xevinapant (AT406, ARRY-334543, Debio1143, SM-406) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.
Nat Commun, 2025, 16(1):2572
Cell Death Dis, 2025, 16(1):476
bioRxiv, 2025, 2025.09.22.677496
Verified customer review of Xevinapant (AT406)
S7010 GDC-0152 GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM in cell-free assays, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.
J Exp Clin Cancer Res, 2024, 43(1):311
Nat Commun, 2023, 14(1):1461
Cell Rep, 2023, 42(1):111965
Verified customer review of GDC-0152
S7089 SM-164 SM-164 is a potent, non-peptide, cell-permeable antagonist of XIAP that targets both the BIR2 and BIR3 domains with IC50 of 1.39 nM. This compound induces apoptosis and tumor regression.
Nature, 2025, 10.1038/s41586-025-09741-1
EMBO J, 2025, 10.1038/s44318-025-00412-5
J Virol, 2025, 99(3):e0198024
S7362 AZD5582 AZD5582, a novel small-molecule IAP inhibitor, binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15
EMBO J, 2025, 10.1038/s44318-025-00412-5
Cell Rep, 2024, 43(7):114400
Cell Death Dis, 2023, 14(9):599
S8681 Tolinapant (ASTX660) Tolinapant (ASTX660) is a potent, non-peptidomimetic antagonist of cIAP1/2 and XIAP that inhibits the interactions between a SMAC-derived peptide and the BIR3 domains of XIAP (BIR3-XIAP) and cIAP1 (BIR3-cIAP1) with IC50 values less than 40 and 12 nmol/L, respectively.
Cell Death Differ, 2024, 31(10):1318-1332
Cell Death Differ, 2024, 10.1038/s41418-024-01316-3
bioRxiv, 2024, 2024.12.12.628190