DOCK

Other GPCR & G Protein Related Inhibitors

Hedgehog/Smoothened PKA CGRP Receptor Endothelin Receptor S1P Receptor Cannabinoid Receptor SGLT Opioid Receptor GPR CCR

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S0899	CPYPP	CPYPP is an inhibitor of dedicator of cytokinesis 2 (DOCK2). This compound inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2^DHR-2 for Rac1 in a dose-dependent manner with IC50 of 22.8 μM. It also inhibits DOCK180, DOCK5 and less DOCK9.	Front Immunol, 2022, 13:982383
S0978	TBOPP	TBOPP is a selective inhibitor of dedicator of cytokinesis (DOCK1, Dock180) that inhibits DOCK1-mediated Rac activation with IC50 of 8.4 μM. This compound binds to the DOCK1 DHR-2 domain with Kd of 7.1 μM. It exhibits anti-tumor activity.