Home Transmembrane Transporters Chloride Channel

Chloride Channel Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S2955 NS1652 NS1652 is a reversible chloride channel blocker, potently inhibits the chloride conductance (IC50 = 1.6 μM) in human and mouse red blood cells, but only weakly volume activated anion conductance (VRAC) (IC50 = 125 μM) in HEK293 cells.
S8279 (Rac)-Shikonin (±)-Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.
Oncol Rep, 2026, 55(5)94
Signal Transduct Target Ther, 2025, 10(1):341
J Exp Clin Cancer Res, 2025, 44(1):299
S6439 Talniflumate Talniflumate (MSI-1995) is an anti-inflammatory molecule studied and used as a mucin regulator in the treatment of cystic fibrosis, chronic obstructive pulmonary disease (COPD) and asthma. This compound is also an inhibitor of human calcium-activated chloride channels.
Acta Pharmaceutica Sinica B, February 2023, 662-677
Toxicol Lett, 2025, 406:31-37
Acta Pharmaceutica Sinica B, 2023, 662-677
S6470 Fluralaner Fluralaner (A1443, AH252723) is a systemic insecticide and acaricide that is administered orally. This compound inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) and L-glutamate-gated chloride channels (GluCls)
Biochem Pharmacol, 2026, 250(Pt 1):117962
S4339 Meticrane Meticrane is a diuretic that inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. This compound is used to treat essential hypertension.