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Autophagy Antagonist

Cat.No. Product Name Information Product Use Citations Product Validations
S7307 GSK2606414 GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. This compound impairs GANT-61 induced autophagy in NB cells with MYCN amplification. It exacerbates ER stress-induced apoptosis in HCT116 cells while reduces the apoptosis in SIL1 KD HeLa cells.
Immunity, 2025, 58(10):2489-2504.e8
J Transl Med, 2025, 23(1):860
Biomolecules, 2025, 15(1)76
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