Tyrosinase Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S4132	Deoxyarbutin	DeoxyArbutin(D-arbutin,D-Arb) is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM.
S4571	Hexylresorcinol	Hexylresorcinol (4-Hexylresorcinol) is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, and is a potent inhibitor of mushroom tyrosinase. The IC50 values of this compound for monophenolase is 1.24 μM and for diphenolase is 0.85 μM.
S6272	Glycolic acid	Glycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, this compound is often used in skin care products, most often as a chemical peel. It is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
E2861	Kojic acid dipalmitate	Kojic acid is a slow-binding inhibitor of catecholase activity of tyrosinase with a Ki of 2.75 µM.
S9284	Aloesin	Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.
S4997	4-Butylresorcinol	4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.
S3691	4-Chlorosalicylic acid	4-Chlorosalicylic acid (4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid) was used in sensitive spectrofluorometric determination of terbium in mixed rare earths and preparation of poly(4-chlorosalicylic acid-formaldehyde) via condensation with formaldehyde. This compound is a pharmaceutical intermediate. It inhibits monophenolase and diphenolase activity with IC50s of 1.89 mM and 1.10 mM. It has potent antimicrobial activity. It is active against E. coli with the MIC of 250 μg/mL and with the MBC of 500 μg/mL.
E2908	1-PHENYL-2-THIOUREA	1-PHENYL-2-THIOUREA(N-Phenylthiourea, PTU, Phenylthiocarbamide) is an inhibitor of tyrosinase (Tyr). This compound blocks pigmentation and improves optical transparency in zebrafish (Danio rerio) embryo.
S9089	Magnoflorine	Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.
S3166	Calcium 2-oxoglutarate	Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) is the Calcium salt form of 2-oxoglutarate. 2-oxoglutarate is naturally found in organisms and is a well-known intermediate in the production of ATP or GTP in the Krebs cycle. 2-oxoglutarate is a reversible inhibitor of tyrosinase with IC50 of 15 mM.
S9376	Benzylacetone	Benzylacetone (4-Phenyl-2-butanone, Methyl 2-phenylethyl ketone) is an attractant compound in flowers. This compound exhibits potent and reversible antityrosinase (mushroom) activity, with IC50s of 2.8 mM and 0.6 mM for monophenolase and diphenolase, respectively.
S6221	Methyl cinnamate	Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.
S4921	MNS (3,4-Methylenedioxy-β-nitrostyrene)	MNS (3,4-Methylenedioxy-β-nitrostyrene) is a tyrosine kinase inhibitor that inhibits Syk, Src, and p97 with IC50 values of 2.5 μM, 29.3 μM, and 1.7 μM, respectively.	Journal of Biomedical Engineering, 2021, 38(5):903-910 Phytomedicine, 2019, 61:152859 J Biomol Struct Dyn, 2019, 10.1080/07391102.2019.1640133
E1791	Zongertinib (BI 1810631)	Zongertinib (BI 1810631, BI 764532) is a selective and potent inhibitor of human HER2 and EGFR tyrosine kinase that covalently binds to both wild-type and mutated HER2 receptors, including exon 20 insertion mutations, while sparing EGFR signaling. It exhibits effective and tolerable oral treatment for patients with HER2 aberration-positive solid tumors.	Cancer Discov, 2025, 10.1158/2159-8290.CD-25-0605
E1509	Bezuclastinib	Bezuclastinib(CGT9486; PLX 9486) is a potent inhibitor of c-kit and c-kit D816V with an IC50 value of <1 μM. This compound is also an inhibitor of tyrosine kinase.