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PI3K Activators

Cat.No. Product Name Information Product Use Citations Product Validations
S7865 740 Y-P (PDGFR 740Y-P) 740 Y-P (PDGFR 740Y-P, 740YPDGFR) is a cell-permeable phosphopeptide activator of PI3K.
Cell Death Dis, 2025, 16(1):538
Biochim Biophys Acta Mol Basis Dis, 2025, 1871(7):167920
World J Diabetes, 2025, 16(5):102196
E0785 YS-49 YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells, inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1, also is an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors.
Cell Signal, 2025, 131:111752
Signal Transduct Target Ther, 2024, 9(1):243
E1579 UCL-TRO-1938 UCL-TRO-1938 is a potent allosteric activator of PI3Kα . This compound can induce cell proliferation and has cardioprotective and neural regeneration effects.
S5383 Erucic acid Erucic acid (cis-13-docosenoic acid) is a monounsaturated omega-9 fatty acid used as mineral oil and a precursor to biodiesel fuel.
E3017 Poria Cocos Extract Poria Cocos Extract is extracted from Poria cocos, which can stimulate aquaporin-3 via the PI3K/Akt/mTOR signaling pathway.
S3294 Demethyl-Coclaurine Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. This compound stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes.
Signal Transduct Target Ther, 2024, 9(1):243
E2947 Recilisib Recilisib (ON01210, EX-RAD) is a radioprotectant that activates the activity of AKT and PI3K in cells. It has been studied as prophylactic (use prior to radiation exposure) and therapeutic (after exposure to radiation) drug.