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PAR Antagonists

Cat.No. Product Name Information Product Use Citations Product Validations
S8067 Vorapaxar (MK-5348) Vorapaxar (SCH 530348, MK-5348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.
Cell Rep Med, 2025, 6(10):102371
Cardiovasc Diabetol, 2025, 24(1):323
J Immunother Cancer, 2024, 12(11)e009805
S9744 AZ3451 AZ3451 is a potent antagonist of protease-activated receptor 2 (PAR2) that binds to a remote allosteric site outside the helical bundle with IC50 of 23 nM.
Front Immunol, 2024, 15:1477072
E0102 I-191 I-191 is a potent PAR2 antagonist that inhibits multiple PAR2-induced signaling pathways and functional responses. This compound also inhibits ERK1/2 phosphorylation, RhoA activation, and inhibition of forskolin-stimulated cAMP accumulation induced by micromolar concentrations of biased ligand GB88.
Front Immunol, 2024, 15:1477072
E4841 Vorapaxar sulfate Vorapaxar sulfate (SCH 530348 sulfate) is a selective and orally active antagonist of protease-activated receptor (PAR-1), with a Ki value of 8.1 nM. This compound reduces thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner.
S0342 Atopaxar Atopaxar(E5555,ER-172594-00) is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist.
S9916 SCH79797 dihydrochloride SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist, which can inhibit binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM.