Microtubule Associated Modulators

Cat.No.	Product Name	Information	Product Use Citations
S3374	Verubulin hydrochloride	Verubulin hydrochloride(MPC 6827 hydrochloride) is a microtubule destabilizer and vascular disrupting agent that achieve high brain concentration relative to plasma in animals.
S1233	2-Methoxyestradiol (2-MeOE2)	2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. This compound also induces both autophagy and apoptosis in various carcinogenic cell lines.	Nat Commun, 2025, 16(1):4681 Int J Nanomedicine, 2025, 20:933-950 Theranostics, 2024, 14(13):5123-5140
S1176	Plinabulin	Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.	J Med Chem, 2022, 65(13):9159-9173 ACS Omega, 2022, 7(25):21465-21472 J Biol Chem, 2019, 294(20):8161-8170
S0360	EGFR Inhibitor	EGFR inhibitor, a cell permeable, 4,6-disubstituted pyrimidine compound, is a highly selevtive inhibitor of EGFR kinase with IC50 of 21 nM. EGFR inhibitor directly depolymerizes microtubules and is used as a chemical probe to investigate both the EGFR pathway and microtubule dynamics.	Cell Rep, 2022, 40-8:111223 Cancers (Basel), 2022, 14(19)4910 PLoS pathogens, 2016, 10.1371/journal.ppat.1005926