DPP-4

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

click to view more

Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No. Information Product Use Citations Product Validations
S4002

Sitagliptin phosphate monohydrate

Sitagliptin phosphate monohydrate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.

S3031

Linagliptin

Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.

S3033

Vildagliptin (LAF-237)

Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM.

S1540

Saxagliptin

Saxagliptin is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

S2868

Alogliptin

Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

S4697New

Saxagliptin hydrate

Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

S4636New

Teneligliptin hydrobromide

Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

S7513

Trelagliptin

Trelagliptin is a highly selective, long-acting DPP-4 inhibitor. Phase 3.

Catalog No. Information Product Use Citations Product Validations
S4002

Sitagliptin phosphate monohydrate

Sitagliptin phosphate monohydrate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.

S3031

Linagliptin

Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.

S3033

Vildagliptin (LAF-237)

Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM.

S1540

Saxagliptin

Saxagliptin is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

S2868

Alogliptin

Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

S4697New

Saxagliptin hydrate

Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

S4636New

Teneligliptin hydrobromide

Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

S7513

Trelagliptin

Trelagliptin is a highly selective, long-acting DPP-4 inhibitor. Phase 3.

Tags: DPP-4 inhibition | DPP-4 inhibitor diabetes | DPP-4 enzyme | DPP-4 inhibitors mechanism | DPP-4 drugs | DPP-4 cancer | DPP-4 inhibitors list | DPP-4 activity | DPP-4 inhibitors drugs | DPP-4 inhibitors review | new DPP-4 inhibitor | DPP-4 assay | DPP-4 inhibitors cancer | FDA approved DPP-4 inhibitors