Home Angiogenesis -Protein Tyrosine Kinase FLT3 FLT3-ITD Inhibitors

FLT3-ITD Inhibitors

  • FLT3-WT
  • FLT3-ITD
  • FLT3-D835Y
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S9892 HM43239

HM43239 is a novel potent small molecule FLT3 inhibitor that selectively inhibits not only FLT3 wild type, ITD mutants or TKD mutations, but also FLT3 ITD/TKD double mutations. IC50s' of HM43239 against FLT3 WT, FLT3 ITD and FLT3 D835Y kinases are 1.1 nM, 1.8 nM and 1.0 nM, respectively.

 Pan FLT3-ITD, IC50: 1.8 nM