Verteporfin: Selectivity & Specificity
Verteporfin is a potent inhibitor of GLK (1.15 nM), HPK1 (7.91 nM), YAP1, TAZ, TEAD, p62, STAT3, Lamin A/C, Lamin B1, CCN1, GPX4, HIF-1α, VEGF, FAT1, Survivin, 14-3-3σ, CD44, ALDH, TAp73, TrxR, MDM2-p73 complex, MDMX-p73 complex, AhR-RORγt complex, IL-17A, COX2, FAK, and ROCK2. Verteporfin exhibits the greatest inhibitory potency toward GLK (IC50 = 1.15 nM).