Verteporfin is a potent YAP inhibitor and photosensitizer. It affects Hippo-YAP and mTOR signaling pathways by disrupting YAP-TEAD interactions and generating reactive oxygen species upon light activation, thereby inhibiting cell proliferation, migration, and fibrosis, and promoting apoptosis.
Verteporfin IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Verteporfin Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.