STM2457 is a potent, specific METTL3 inhibitor. It affects interferon-gamma, NF-κB, mTOR and MAPK signaling pathways. By inhibiting METTL3 enzymatic activity and reducing global m6A RNA methylation, it inhibits cancer cell proliferation, chemoresistance, and inflammation.
STM2457 Mechanism of Action: METTL3 Inhibition in Leukemia Stem Cells Research
STM2457 MOA：Targeting METTL3/m6A RNA Methylation Pathway for Acute Myeloid Leukemia