STM2457 is a potent, specific METTL3 inhibitor. It affects interferon-gamma, NF-κB, mTOR and MAPK signaling pathways. By inhibiting METTL3 enzymatic activity and reducing global m6A RNA methylation, it inhibits cancer cell proliferation, chemoresistance, and inflammation.
STM2457 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for STM2457 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.