CAS No. 2499663-01-1
| IUPAC Name | N-[[6-[(cyclohexylmethylamino)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxopyrido[1,2-a]pyrimidine-2-carboxamide | |
|---|---|---|
| CAS Number | 2499663-01-1 | |
| Molecular Formula |
C25H28N6O2 |
|
| Molecular Weight (MW) | 444.53 | |
| SMILES | O=C(NCC1=C[N]2C=C(CNCC3CCCCC3)C=CC2=N1)C4=CC(=O)N5C=CC=CC5=N4 | |
| InChIKey | OBERVORNENYOLE-UHFFFAOYSA-N |
STM2457 is a selective, first-in-class catalytic inhibitor of RNA methyltransferase METTL3 (IC50 =. By directly inhibiting METTL3 catalytic activity, STM2457 substantially reduces intracellular m6A RNA methylation levels, leading to downstream downregulation of oncogenic pathways. This inhibition selectively impairs cell proliferation, promotes myeloid differentiation, and induces apoptosis in acute myeloid leukemia cell models while demonstrating high specificity over other RNA methyltransferases. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
125 mg/mL
(281.19 mM)
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 89 mg/mL |
| Water | Insoluble |
| DMSO |
89 mg/mL
(200.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 89 mg/mL |
| Water | Insoluble |
| DMSO |
88 mg/mL
(197.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 88 mg/mL |
| Water | Insoluble |
| DMSO |
22 mg/mL
(49.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
| DMSO |
18 mg/mL
(40.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 18 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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- STM2457 Mechanism of Action: METTL3 Inhibition in Leukemia Stem Cells Research
- STM2457: Selectivity & Specificity
- STM2457 Working Concentration | Cell Culture | Treatment
- STM2457 Solubility in DMSO
- STM2457 Stock Solution
- STM2457 Storage
- STM2457 Stability
- STM2457 Combination Database
- STM2457 Molecular Weight
- STM2457 SMILES
- STM2457 Chemical Structure (2D and 3D)
- STM2457 IC50 for Cell-based and Cell-free Assays
- STM2457 Sigma (SML3360)? Try a better option.
- STM2457 MedChemExpress (HY-134836)? Try a better option.
- STM2457 Cayman (34280)? Try a better option.
- STM2457 Abmole (M11368)? Try a better option.
- STM2457 SDS｜MSDS