Target Selectivity of Sorafenib (BAY 43-9006)
| Key Target | IC50 | Description | Reference |
|---|---|---|---|
| RAF1 | 6 nM | -- | PMC10085060 |
| VEGFR2 | 8.99 nM | Human VEGFR-2 (KDR) kinase assay kit, luminescence detection | PMC11860020 |
| VEGFR-2 | 0.22 mM | Enzyme-linked immunosorbent assay kit | PMC12977370 |
| VEGFR-2 | 0.84 mM | Anti-phosphotyrosine antibody with the Alpha Screen system | PMC12973379 |
| EGFR | 0.76 mg/ml | EGFR Kinase Assay Kit; Luminescence measurement using microplate reader; IC50 values calculated using GraphPad Prism 5.0 software. | PMC11413560 |
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Sorafenib (BAY 43-9006)
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- Sorafenib (BAY 43-9006) Mechanism of Action: Raf Inhibition in Hepatocellular Carcinoma Cell Research
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