Sorafenib (BAY 43-9006) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

• Product Name: Sorafenib (BAY 43-9006)
• Catalog Number: S7397
• CAS Number: 284461-73-0
• IUPAC Name: 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide

Relevant identified uses and uses advised against

• Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
• Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

• Company : Selleck Chemicals
• TollFree : +1 877 796-6397
• Tel : +1 832 582-8158
• Fax : +1 832 582-8590

Emergency telephone number

• Emergency phone #: +1 832 582-8158

2. HAZARDS IDENTIFICATION

GHS Classification

• Reproductive toxicity: Category 1B
• Effects on or via lactation
• Specific target organ toxicity - repeated exposure: Category 1
• Short-term (acute) aquatic hazard: Category 1
• Long-term (chronic) aquatic hazard: Category 1

Pictogram: ,

Signal word: Danger

Hazard statements

• H360: May damage fertility or the unborn child.
• H362: May cause harm to breast-fed children.
• H372: Causes damage to organs through prolonged or repeated exposure.
• H410: Very toxic to aquatic life with long lasting effects.

Precautionary statements

• P201: Obtain special instructions before use.
• P202: Do not handle until all safety precautions have been read and understood.
• P260: Do not breathe powder.
• P263: Avoid contact during pregnancy/while nursing.
• P264: Wash skin thoroughly after handling.
• P270: Do not eat, drink or smoke when using this product.
• P273: Avoid release to the environment.
• P280: Wear protective gloves/protective clothing/eye protection/face protection.
• P308 + P313: IF exposed or concerned: Get medical advice/attention.
• P391: Collect spillage.
• P405: Store locked up.
• P501: Dispose of contents/container to an approved waste disposal plant.

Other hazards
None known.

3. COMPOSITION/INFORMATION ON INGREDIENTS

Substance / Mixture: Substance
CAS-No.: 284461-73-0

Components

• Chemical Name: 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
• CAS No.: 284461-73-0
• Concentration (% w/w): >= 90 - <= 100%
• Trade Secret: Actual concentration is withheld as a trade secret.

4. FIRST AID MEASURES

General advice: Show this safety data sheet to the doctor in attendance.
If inhaled: After inhalation: fresh air. Call in physician.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/shower. Consult a physician.
In case of eye contact: After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed: After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
Most important symptoms and effects, both acute and delayed: The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11.
Protection of first-aiders: For personal protection see section 8.
Notes to physician: N/A.

5. FIREFIGHTING MEASURES

Suitable extinguishing media: Water, Foam, Carbon dioxide (CO2), Dry powder.
Unsuitable extinguishing media: For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during firefighting: Combustible. Development of hazardous combustion gases or vapours possible in the event of fire.
Hazardous combustion products: Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas, Hydrogen fluoride.
Specific extinguishing methods: N/A.
Further information: Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters: Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures: Advice for non-emergency personnel: Avoid generation and inhalation of powder in all circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.
Environmental precautions: Do not let product enter drains.
Methods and materials for containment and cleaning up: Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of powder.

7. HANDLING AND STORAGE

Advice on safe handling: Work under hood. Do not inhale substance/mixture. For precautions see section 2.
Further information on storage conditions: Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorised persons.
Storage class: 6.1D, Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects.
Recommended storage temperature: 36 - 46 °F / 2 - 8 °C.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Ingredients with workplace control parameters: Contains no substances with occupational exposure limit values.
Engineering measures: N/A.
Personal protective equipment

• Respiratory protection: Required when powder is generated. Recommended Filter type: Filter type P3 (based on DIN EN 143, DIN 14387).
• Hand protection: Nitrile rubber gloves. Full contact/Splash contact: Material thickness 0.11 mm, Break through time 480 min (e.g., KCL 741 Dermatril L).
• Eye protection: Safety glasses tested and approved under appropriate government standards such as NIOSH (US) or EN 166 (EU).
• Skin and body protection: Protective clothing.
• Hygiene measures: Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

9. PHYSICAL AND CHEMICAL PROPERTIES

• Appearance: powder
• Color: N/A
• Odor: N/A
• Odor Threshold: N/A
• pH: N/A
• Melting point: 386.8 °F / 197.1 °C
• Boiling point: Decomposes below the boiling point.
• Flash point: N/A
• Evaporation rate: N/A
• Flammability (powder, gas): The product is not flammable.
• Flammability (liquids): N/A
• Burning rate: N/A
• Upper/Lower explosion limit: N/A
• Vapor pressure: N/A
• Relative vapour density: N/A
• Relative density: N/A
• Density: 1.46 g/cm3 (68 °F / 20 °C)
• Water solubility: 0.0001 g/l (77 °F / 25 °C)
• Partition coefficient: n-octanol/water: log Pow: 3.3 (77 °F / 25 °C). Bioaccumulation is not expected.
• Autoignition temperature: N/A
• Decomposition temperature: > 491 °F / > 255 °C
• Viscosity: N/A
• Flow time: N/A
• Explosive properties: N/A
• Oxidizing properties: None
• Molecular weight: 464.82 g/mol
• Particle size: N/A

10. STABILITY AND REACTIVITY

Reactivity: Flammable organic substances in fine distribution may have a powder explosion potential when whirled up.
Chemical stability: The product is chemically stable under standard ambient conditions (room temperature).
Possibility of hazardous reactions: N/A.
Conditions to avoid: No information available.
Incompatible materials: Strong oxidizing agents.
Hazardous decomposition products: In the event of fire: see section 5.

11. TOXICOLOGICAL INFORMATION

11.1 Information on toxicological effects

• Acute toxicity: LD50 Oral - Rat - male and female - > 2,000 mg/kg (OECD 401). LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD 402). Inhalation: N/A.
• Skin corrosion/irritation: Skin - Rabbit: No irritation - 4 h (OECD 404).
• Serious eye damage/eye irritation: Eyes - Rabbit: Slight irritation (OECD 405).
• Respiratory or skin sensitization: Local lymph node assay (LLNA) - Mouse: Negative (OECD 429).
• Germ cell mutagenicity: Ames test (Salmonella typhimurium): Negative. Chromosome aberration test in vitro (Chinese hamster lung cells): Positive. Micronucleus (Mouse bone marrow): Negative.
• Carcinogenicity: IARC, NTP, and OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen.
• Reproductive toxicity: May damage the unborn child. May damage fertility. Studies indicate a hazard to babies during the lactation period.
• STOT - single exposure: N/A.
• STOT - repeated exposure: Causes damage to organs through prolonged or repeated exposure.
• Aspiration hazard: N/A.

11.2 Additional Information
RTECS: US4588870. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

12. ECOLOGICAL INFORMATION

Ecotoxicity

• Toxicity to fish: LC0 (Danio rerio): >= 0.012 mg/l - 96 h.
• Toxicity to daphnia: EC0 (Daphnia magna): >= 0.031 mg/l - 48 h.
• Toxicity to algae: ErC50 (Desmodesmus subspicatus): > 0.001 mg/l - 72 h.
• M-Factor (Acute aquatic toxicity): 100
• Toxicity to fish (Chronic): NOEC (Pimephales promelas): 0.0024 mg/l - 28 d.
• Toxicity to daphnia (Chronic): NOEC (Daphnia magna): >= 0.001 mg/l - 21 d.
• M-Factor (Chronic aquatic toxicity): 100
• Toxicity to microorganisms: NOEC (activated sludge): >= 32 mg/l - 30 min.

Persistence and degradability: Aerobic biodegradability (activated sludge): 2% - 28 d (Not biodegradable).
Bioaccumulative potential: log Pow: 3.3. Bioaccumulation is not expected.
Mobility in soil: N/A.
Other adverse effects: N/A.

13. DISPOSAL CONSIDERATIONS

Waste from residues: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers

16. OTHER INFORMATION

Revision Date: 2026/07/08
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.