SN-38 is a potent topoisomerase I inhibitor. It affects p53, ATR/CHK1, and PI3K/AKT/NF-κB signaling pathways by stabilizing TOP1 cleavage complexes and inducing DNA double-strand breaks, thereby inhibiting tumor cell proliferation and promoting apoptosis.
SN-38: Mechanism of Action
SN-38 MOA：Targeting Topoisomerase I/DNA Damage Response Pathway for Antibody-Drug Conjugates
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- SN-38 IC50 for Cell-based and Cell-free Assays
- SN-38 Sigma (H0165)? Try a better option.
- SN-38 APExBIO (N2133)? Try a better option.
- SN-38 Cayman (15632)? Try a better option.
- SN-38 MedChemExpress (HY-13704)? Try a better option.
- SN-38 SDS｜MSDS