SN-38 is a potent topoisomerase I inhibitor. It affects p53, ATR/CHK1, and PI3K/AKT/NF-κB signaling pathways by stabilizing TOP1 cleavage complexes and inducing DNA double-strand breaks, thereby inhibiting tumor cell proliferation and promoting apoptosis.
SN-38 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for SN-38 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.
Jump to
- SN-38 Mechanism of Action: Topoisomerase I Inhibition in Cancer Cell Research
- SN-38 Clinical Trials
- SN-38 Working Concentration | Cell Culture | Treatment
- SN-38 Solubility in DMSO
- SN-38 Stock Solution
- SN-38 Storage
- SN-38 Stability
- SN-38 Combination Database
- SN-38 Molecular Weight
- SN-38 SMILES
- SN-38 CAS Number
- SN-38 Chemical Structure (2D and 3D)
- SN-38 Sigma (H0165)? Try a better option.
- SN-38 APExBIO (N2133)? Try a better option.
- SN-38 Cayman (15632)? Try a better option.
- SN-38 MedChemExpress (HY-13704)? Try a better option.
- SN-38 SDS｜MSDS