AZD6244 (Selumetinib): Selectivity & Specificity

AZD6244 (Selumetinib) is a potent inhibitor of Purified MEK (12 nM), MEK1 (14 nM), MEK2 (14 nM), ERK1, ERK2. AZD6244 (Selumetinib) exhibits the greatest inhibitory potency toward Purified MEK (IC50 = 12 nM).