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Rusfertide(PTG-300)

Cat.No.P1254

Rusfertide (PTG-300) is a hepcidin mimetic that targets ferroportin, inducing its internalization and degradation to block cellular iron export into the blood. By limiting transferrin saturation (TSAT), it reduces systemic labile iron toxicity and prevents organ iron deposition. Rusfertide exhibits the potential treatment for Hereditary Hemochromatosis and hemoglobinopathies like beta-thalassemia and also helps to improve anemia by promoting more effective erythropoiesis.

Amino-acid Sequence

Rusfertide(PTG-300) Amino-acid Sequence

CAS No. 1628323-80-7

Quality Control

Batch: P125401 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] Insoluble] false Purity: 98.75%
98.75

Chemical Information & Solubility

Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL (40.95 mM)；
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Biological Activity

Description Rusfertide (PTG-300) is a hepcidin mimetic that targets ferroportin, inducing its internalization and degradation to block cellular iron export into the blood. By limiting transferrin saturation (TSAT), it reduces systemic labile iron toxicity and prevents organ iron deposition. Rusfertide exhibits the potential treatment for Hereditary Hemochromatosis and hemoglobinopathies like beta-thalassemia and also helps to improve anemia by promoting more effective erythropoiesis.

References
  • https://www.sciencedirect.com/science/article/pii/S0006497118614685
  • https://pubmed.ncbi.nlm.nih.gov/39546273/

Product Information

Molecular Formula

C114H181N27O28S2
Molecular Weight 2441.96
CAS No. 1628323-80-7
Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)