CAS No. 53123-88-9
Batch:
Purity:99.63
Chemical Structure
Check the
Rapamycin (Sirolimus)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone | |
|---|---|---|
| CAS Number | 53123-88-9 | |
| Molecular Formula |
C51H79NO13 |
|
| Molecular Weight (MW) | 914.18 | |
| SMILES | CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC | |
| InChIKey | QFJCIRLUMZQUOT-HPLJOQBZSA-N |
Rapamycin (Sirolimus) is a specific mTOR inhibitor that complexes with FKBP12 to allosterically inhibit the mTORC1 complex. Disruption of mTORC1 downstream signaling leads to the suppression of protein synthesis, cell cycle progression, and cellular proliferation while potently triggering autophagy. Furthermore, rapamycin inhibits interleukin-mediated hematopoietic bone marrow cell expansion and functions as an effective immunosuppressant that prevents graft rejection in allogeneic transplantation models. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(109.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(109.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 40 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(109.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(109.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(109.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Rapamycin (Sirolimus) Mechanism of Action: mTOR Inhibition in Senescent Cells Research
- Rapamycin (Sirolimus) Clinical Trials
- Rapamycin (Sirolimus): Selectivity & Specificity
- Rapamycin (Sirolimus) Working Concentration | Cell Culture | Treatment
- Rapamycin (Sirolimus) Solubility in DMSO
- Rapamycin (Sirolimus) Stock Solution
- Rapamycin (Sirolimus) Storage
- Rapamycin (Sirolimus) Stability
- Rapamycin (Sirolimus) Combination Database
- Rapamycin (Sirolimus) Molecular Weight
- Rapamycin (Sirolimus) SMILES
- Rapamycin (Sirolimus) Chemical Structure (2D and 3D)
- Rapamycin (Sirolimus) IC50 for Cell-based and Cell-free Assays
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- Rapamycin (Sirolimus) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.