Rapamycin (Sirolimus): Mechanism of Action

Rapamycin (Sirolimus) MOA:Targeting mTOR/mTORC1 for Geroscience and Longevity Medicine

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Rapamycin (Sirolimus) is a potent, selective mTOR inhibitor. It affects PI3K/AKT/mTOR signaling, inhibiting cell proliferation and tumor growth by binding to FKBP12 to suppress mTORC1 activity and inducing autophagy.

Primary Applications and Mechanism of Action