PX-478 Dihydrochloride: Selectivity & Specificity
PX-478 Dihydrochloride is a potent inhibitor of HIF-1α (30500 nM), Drp1, Fis1, METTL3, NLRP3, Caspase-1, IL-18, IL-1β, BNIP3, FUNDC1, NIX, PARKIN, PINK1, VEGF, LC3, Beclin1, BCL2, Caspase-3, p62, circ-0100519, NRF2, USP7, CD31, VEGF-A, FGFR-1, LC3B, TOMM20, COX IV, BMAL1, TWIST, N-Cadherin, Vimentin. PX-478 Dihydrochloride exhibits the greatest inhibitory potency toward HIF-1α (IC50 = 30500 nM).