PX-478 Dihydrochloride Solubility in DMSO

Size	Price	Qty
1mg*5	USD 147
25mg	USD 477

In Vitro Solubility

Batch:

All in vitro solubility values are batch-tested experimental data (non-literature values).

Solvent	Solubility & Note
DMSO	79 mg/mL (200.44 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water	79 mg/mL
Ethanol	79 mg/mL
DMSO	79 mg/mL (200.44 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water	79 mg/mL
Ethanol	79 mg/mL
DMSO	79 mg/mL (200.44 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water	79 mg/mL
Ethanol	79 mg/mL
DMSO	79 mg/mL (200.44 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water	79 mg/mL
Ethanol	79 mg/mL
DMSO	79 mg/mL (200.44 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water	79 mg/mL
Ethanol	20 mg/mL

FAQ

Q: Why does a DMSO stock precipitate in media/saline?

A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.

How to fix it?

Preheat media/saline to 37°C.
Mix rapidly (pipette/vortex) upon addition.
For complex mixes, always add the aqueous phase last.
Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Check the PX-478 Dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Formulation for Animal Experiments

Batch:

Administration Route	Formulation Type	Formulation Details	Solubility	Preparation Method
Injection	Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.950mg/mL (10.02mM)	Taking the 1 mL working solution as an example, add 50 μL of clarified DMSO stock solution of 79 mg/ml to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Injection	Clear solution	saline Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	10.000mg/mL (25.37mM)	Taking the 1 mL working solution as an example, add 10 mg of product to 1 ml of physiological saline (0.9% NaCL solution), and shake to clarify. The mixed solution should be used immediately for optimal results.
Oral Administration	Homogeneous suspensionCMC-NA	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Oral Administration	Homogeneous suspensionCMC-NA	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Oral Administration	Homogeneous suspensionCMC-NA	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Oral Administration	Homogeneous suspensionCMC-NA	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Oral Administration	Homogeneous suspensionCMC-NA	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

Recommended and Maximum Dosing Volumes for Animal Experiments

Other Animals:

🐁 In Vivo Formulation Calculator

Dosage: mg/kg

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Avg Wt: g

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Vol/Animal: μL

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Animals:

% DMSO

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% PEG300

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% Tween 80

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% ddH₂O

PX-478 Dihydrochloride Solubility

Table of Contents

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In Vitro Solubility

Formulation for Animal Experiments

Recommended and Maximum Dosing Volumes for Animal Experiments

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