CAS No. 685898-44-6
Batch:
Purity:97
Chemical Structure
Check the
PX-478 Dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[(2S)-2-amino-2-carboxyethyl]-N,N-bis(2-chloroethyl)benzeneamine oxide;dihydrochloride | |
|---|---|---|
| CAS Number | 685898-44-6 | |
| Molecular Formula |
C13H20Cl4N2O3 |
|
| Molecular Weight (MW) | 394.12 | |
| SMILES | C1=CC(=CC=C1CC(C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl | |
| InChIKey | GIGCDIVNDFQKRA-LTCKWSDVSA-N |
PX-478 dihydrochloride is an orally active, selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. It suppresses HIF-1α protein accumulation under hypoxic conditions without altering HIF-1α mRNA expression. Downstream, PX-478 decreases hypoxia-induced transcription of target genes such as VEGF. Consequently, the compound induces apoptosis, reduces tumor vascularization, and demonstrates potent anti-tumor activity in preclinical tumor xenograft models. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(200.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 79 mg/mL |
| Ethanol | 79 mg/mL |
| DMSO |
79 mg/mL
(200.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 79 mg/mL |
| Ethanol | 79 mg/mL |
| DMSO |
79 mg/mL
(200.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 79 mg/mL |
| Ethanol | 79 mg/mL |
| DMSO |
79 mg/mL
(200.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 79 mg/mL |
| Ethanol | 79 mg/mL |
| DMSO |
79 mg/mL
(200.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 79 mg/mL |
| Ethanol | 20 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- PX-478 Dihydrochloride Mechanism of Action: HIF-1α Inhibition in Tumor Cell Research
- PX-478 Dihydrochloride Clinical Trials
- PX-478 Dihydrochloride: Selectivity & Specificity
- PX-478 Dihydrochloride Working Concentration | Cell Culture | Treatment
- PX-478 Dihydrochloride Solubility in DMSO
- PX-478 Dihydrochloride Storage
- PX-478 Dihydrochloride Stability
- PX-478 Dihydrochloride Combination Database
- PX-478 Dihydrochloride Molecular Weight
- PX-478 Dihydrochloride SMILES
- PX-478 Dihydrochloride Chemical Structure (2D and 3D)
- PX-478 Dihydrochloride Sigma (ADVH14DBE9DC)? Try a better option.
- PX-478 Dihydrochloride MedChemExpress (HY-10231)? Try a better option.
- PX-478 Dihydrochloride Cayman (10005189)? Try a better option.
- PX-478 Dihydrochloride APExBIO (B6004)? Try a better option.
- PX-478 Dihydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.