Pirfenidone: Selectivity & Specificity
Pirfenidone is a potent inhibitor of TGF-β protein (7080 nM), TNF-α (22810 nM), Hedgehog signaling pathway, PDGF, fibroblast proliferation, collagen synthesis, TGF-β gene expression, TGF-β biosynthesis, α-SMA, PSC, collagen, IL-6, pancreatic macrophage, M1 polarisation, islet fibrosis, WNT/β-catenin pathway, TGF-β/Smad pathway, β-catenin signaling, procollagen transcription, fibroblasts, proinflammatory cytokines, profibrotic cytokines, pirfenidone, stress-activated kinases, SDF-1a/CXCL12, alveolar macrophage activation, ECM deposition, cytochrome P450 1A2, cytokines, PD-L1. Pirfenidone exhibits the greatest inhibitory potency toward TGF-β protein (IC50 = 7080 nM).