CAS No. 53179-13-8
| IUPAC Name | 5-methyl-1-phenylpyridin-2-one | |
|---|---|---|
| CAS Number | 53179-13-8 | |
| Molecular Formula |
C12H11NO |
|
| Molecular Weight (MW) | 185.22 | |
| SMILES | CC1=CN(C(=O)C=C1)C2=CC=CC=C2 | |
| InChIKey | ISWRGOKTTBVCFA-UHFFFAOYSA-N |
Pirfenidone is an orally active anti-fibrotic and anti-inflammatory compound that inhibits transforming growth factor-beta (TGF-β) production and TGF-β-stimulated collagen synthesis. It significantly reduces the expression of pro-inflammatory and pro-fibrotic cytokines, including TNF-α, IL-1β, CCL2, and CCL12. By inhibiting TGF-β/Smad and related signaling cascades, pirfenidone suppresses fibroblast proliferation, attenuates extracellular matrix accumulation, and prevents tissue fibrosis. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
37 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 37 mg/mL |
| Water | Insoluble |
| DMSO |
37 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 37 mg/mL |
| Water | 16 mg/mL |
| DMSO |
37 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 37 mg/mL |
| Water | 10 mg/mL |
| DMSO |
37 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 37 mg/mL |
| Water | Insoluble |
| DMSO |
37 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 37 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
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